JiaBei is a Research Asssociate in the lab. She received her B.S. in Pharmaceutical Engineering from Zhejiang University, her M.S. in Chemistry from Mississippi College, and her Ph.D. in Chemistry from UAB. She enjoys cooking, traveling, and running in her free time. In 2016, JiaBei won an ADDF Young Investigator Scholarship. In 2018, JiaBei won an Alzheimer's Association Research Fellowship. In 2020, JiaBei won a Warren Alpert Foundation Distinguished Scholars Fellowship! In 2023, JiaBei won a Mildred Cohn Distinguished Postdoctoral Award. In 2024, JiaBei won a Biochemistry & Biophysics Department Research Excellence and Resilience Award! In 2024, JiaBei was also selected as a Philadelphia Symposium for Postdoctoral Initiatives in Neuroscience Excellence (P-SPINE) Fellow!
Publications
Lin, J., P.J. Carman, C.W. Gambogi, N.M. Kendsersky, E. Chuang, S.N. Gates, A.L. Yokom, A.N. Rizo, D.R. Southworth, and J. Shorter. (2024). Design principles to tailor Hsp104 therapeutics. Cell Rep. 43(12):115005. pdf file link
The Atomwise Aims Program. (2024). AI is a viable alternative to high throughput screening: a 318-target study. Sci. Rep. 14, 7526. pdf file link
Guo, L.*^, J.R. Mann*, J.C. Mauna°, K.E. Copley°, H. Wang°, J.D. Rubien°, H.M. Odeh, J. Lin, B.L. Lee, L. Ganser, E. Robinson, K.M. Kim, A.C. Murthy, T. Paul, B. Portz, A.M. Gleixner, Z. Diaz, J.L. Carey, A. Smirnov, G. Padilla, E. Lavorando, C. Espy, Y. Shang, E.J. Huang, A. Chesi, N.L. Fawzi, S. Myong, C.J. Donnelly^, and J. Shorter^. (2023). Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. bioRxiv. doi:10.1101/2023.09.04.555754. pdf file link (*Co-first author. °Co-second author. ^Co-corresponding author).
Mack, K.L.*, H. Kim*, E.M. Barbieri, J. Lin, S. Braganza, M.E. Jackrel, J.E. DeNizio, X. Yan, E. Chuang, A. Tariq, R.R. Cupo, L.M. Castellano, K.A. Caldwell, G.A. Caldwell, and J. Shorter. (2023). Tuning Hsp104 specificity to selectively detoxify α-synuclein. Mol. Cell. 83(18):3314-3332.e9. pdf file link (*Co-first author.).
Lin, J.^, J. Shorter^, and A.L. Lucius^. (2022). AAA+ proteins: one motor, multiple ways to work. Biochem. Soc. Trans. 50(2):895-906. pdf file link (^Co-corresponding author).
Huang, L., T. Agrawal, G. Zhu, S. Yu, L. Tao, J. Lin, R. Marmorstein, J. Shorter, and X. Yang. (2021). DAXX represents a new type of protein-folding enabler. Nature. 597(7874):132-37. pdf file link
March, Z.M., K. Sweeney°, H. Kim°, X. Yan°, L.M. Castellano, M.E. Jackrel, J. Lin, E. Chuang, E. Gomes, C. W. Willicott, K. Michalska, R. Jedrzejczak, A. Joachimiak, K.A. Caldwell, G.A. Caldwell, O. Shalem, and J. Shorter. (2020). Therapeutic genetic variation revealed in diverse Hsp104 homologs. eLife. 9:e57457. pdf file link (°Co-second author).
Lopez, K.E.*, A.N. Rizo*, E. Tse, J. Lin, N.W. Skull, A.C. Thwin, A.L. Lucius, J. Shorter, and D.R. Southworth. (2020). Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat. Struct. Mol. Biol. 27(5):406-416. (*Co-first author). pdf file link
Ye, X., J. Lin, L. Mayne, J. Shorter, and S.W. Englander. (2020). Structural and kinetic basis for the regulation and potentiation of Hsp104 function. Proc. Natl. Acad. Sci. U.S.A. 117(17):9384-9392. pdf file link
Jones, R.D., C. Enam, R. Ibarra, H.R. Borror, K.E. Mostoller, E.K. Fredrickson, J. Lin, E. Chuang, Z. March, J. Shorter, T. Ravid, G. Kleiger, and R.G. Gardner. (2020). The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Mol. Biol. Cell. 31(3):221-233. pdf file link
Lopez, K.E., A.N. Rizo, E. Tse, J. Lin, N.W. Skull, A.C. Thwin, A.L. Lucius, J. Shorter, and D.R. Southworth. (2019). Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. BioRxiv. doi: 10.1101/820209. pdf file link (*Co-first author).
Tariq, A.*, J. Lin*, M.E. Jackrel*, C.D. Hesketh, P.J. Carman, K.L. Mack, R. Weitzman, C. Gambogi, O.A. Hernandez Murillo, E.A. Sweeny, E. Gurpinar, A.L. Yokom, S.N. Gates, K. Yee, S. Sudesh, J. Stillman, A.N. Rizo, D.R. Southworth, and J. Shorter. (2019). Mining disaggregase sequence space to safely counter TDP-43, FUS, and alpha-synuclein proteotoxicity. Cell Rep. 28(8):2080–2095. pdf file link (*Co-first author).
Rizo, A.N., J. Lin, S.N. Gates, E. Tse, S.M. Bart, L.M. Castellano, F. DiMaio, J. Shorter, and D.R. Southworth. (2019). Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. Nat. Comm. 10:2393. pdf file link
Durie, C.L., J. Lin, N.W. Scull, K.L. Mack, M.E. Jackrel, E.A. Sweeny, L.M. Castellano, J. Shorter, and A.L. Lucius. (2019). Hsp104 and potentiated variants can operate as distinct non-processive translocases. Biophys. J. 116(10):1856-1872. pdf file link
Ye, X., J. Lin, L. Mayne, J. Shorter, and S.W. Englander. (2019). Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution. Proc. Natl. Acad. Sci. U.S.A. 116(15):7333-7342 pdf file link
Tariq, A.*, J. Lin*, M.M. Noll*, M.P. Torrente, K.L. Mack, O. Hernandez Murillo, M.E. Jackrel, and J. Shorter. (2018). Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain. FEMS Yeast Res. doi: 10.1093/femsyr/foy042. pdf file link (*Co-first author).
Gates, S.N*., A.L. Yokom*, J. Lin, M.E. Jackrel, A.N. Rizo, N.M. Kendsersky, C.E. Buell, E.A. Sweeny, K.L. Mack, E. Chuang, M.P. Torrente, M. Su, J. Shorter, and D.R. Southworth. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348):273-279. pdf file link (*Co-first author).
Weaver, C.L., E.C. Duran, K.L. Mack, J. Lin, M.E. Jackrel, E.A. Sweeny, J. Shorter, and A.L. Lucius. (2017). Avidity for polypeptide binding by nucleotide-bound Hsp104 structures. Biochemistry. 56(15):2071–2075. pdf file link
Lin, J. and A.L. Lucius. (2016). Examination of ClpB quaternary structure and linkage to nucleotide binding. Biochemistry. 55:1758-1771. pdf file link
Lin, J. and A.L. Lucius. (2015). Analysis of Linked Equilibria. Methods Enzymol. 562:161-186. pdf file link
Lin, J. and A.L. Lucius. (2015). Examination of the dynamic assembly equilibrium for E. coli ClpB. Proteins. 83(11):2008-2024. pdf file link
Li, T., J. Lin, and A.L. Lucius. (2015). Examination of polypeptide substrate specificity for Escherichia coli ClpB. Proteins. 83(1):117-134. pdf file link
Li, T., C.L. Weaver, J. Lin, E.C. Duran, J.M. Miller., and A.L. Lucius. (2015) Escherichia coli ClpB is a non-processive polypeptide translocase. Biochem J. 470(1): 39-52. pdf file link
Fancy, R. M., L. Wang, T. Napier, J. Lin, G. Jing, A. L. Lucius, J. M. McDonald, T. Zhou and Y. Song. (2014). Characterization of Calmodulin-Fas Death Domain Interaction: An Integrated Experimental and Computational Study. Biochemistry. 53(16):2680-2688. pdf file link
Miller, J.M., J. Lin, T. Li, and A.L. Lucius. (2013). E.coli ClpA Catalyzed Polypeptide Translocation is Allosterically Controlled by the Protease ClpP. J. Mol Biol. 425(15):2795-2812. pdf file link
